Life Extension BioActive Folate & Vitamin B12 – For Heart, Brain & GI Tract Health – Promotes Nerve Cell Growth, Cognition & Metabolism - Gluten-Free, Non-GMO– 90 Vegetarian Capsules

Top 10 folate supplements Our Picks

Finding a folate supplements that suits your need and does its job well can be challenging. Overall, our tester reviews these folate supplements with giving ratings and marks for its durability, ease of setup and use. Also the folate supplements price will be fairly matched the product’s performance, plus with the attractive and sturdy design etc that comes with the product. We conducted hands-on testing for folate supplements and have the details guide and list provided below.

In this in-depth review guide, we will discuss about the best folate supplements.

Our Top Picks

The Best folate supplements

Doctor's Best Fully Active Folate with Quatrefolic NonGMO Vegan Gluten Free 400 mcg Veggie Caps, 90 Count

$14.99
$8.65
 in stock
7 new from $8.65
Free shipping
as of August 24, 2025 10:02 am

Features

  • Quatrefolic contains the natural form of folic acid. It is the most bioavailable form of folate that provides greater stability and water solubility.
  • Quatrefolic is the metabolically active folate, making it more efficient than folic acid for maximized benefits.
  • Folate is an essential vitamin to support DNA
  • Helps support cardiovascular, mental, and emotional well-being

Life Extension BioActive Folate & Vitamin B12 – For Heart, Brain & GI Tract Health – Promotes Nerve Cell Growth, Cognition & Metabolism - Gluten-Free, Non-GMO– 90 Vegetarian Capsules

$9.00  in stock
as of August 24, 2025 10:02 am

Features

  • Folate in the body – 5-MTHF is the metabolically active form of folic acid and supports healthy DNA function, helps maintain normal homocysteine levels, and supports GI and immune function.
  • Benefits of vitamin B12 – B12 is a vital member of the vitamin B family. The biologically active form of B12, methylcobalamin, supports cognitive health, nerve cell growth and metabolism.
  • The importance of vitamin B – These two biologically active forms of B9 and B12 ensure that you are covering your bases and getting the many benefits of these forms of vitamin B.
  • Ingredients matter – We use the finest raw ingredients with the quality and purity you deserve. The majority of our products are non-GMO, gluten-free and manufactured in the USA—and a Certificate of Analysis is available for every one.     
  • Live your healthiest life – We believe the answers to a healthier life are in reach, and that scientific research is the key to getting there. That’s why so many of our formulas feature specific ingredients and amounts based on scientific studies.

Life Extension Optimized Folate (L-Methylfolate) – Supports Heart & Brain Health – Non-GMO, Gluten-Free, Vegetarian –1700 mcg DFE — 100 Vegetarian Tablets

$11.00  in stock
2 new from $11.00
Free shipping
as of August 24, 2025 10:02 am

Features

  • Get a brain boost – Stay proactive about your brain health and support optimal cognitive function with this folate supplement. This 1700 mcg vitamin B formula helps maintain healthy cognition—especially as you age.
  • Pump up the heart health – This 5-MTHF supplement is a cardiovascular health superstar! Folate helps maintain already-normal homocysteine levels, an important cardiovascular health marker. Folate is a great way to keep heart health in check.
  • Metabolically active form – 5-MTHF, the metabolically active form of folate, is good for your heart and brain health. But not everyone can convert the dietary form of folate (known as folic acid) into 5-MTHF. This supplement provides folate’s 5-MTHF form.
  • Ingredients matter – We use only the finest raw ingredients with the purity and potency you deserve. The majority of our products are non-GMO, gluten-free and manufactured in the USA—and a Certificate of Analysis is available for every one.
  • Live your healthiest life – We believe the answers to a healthier life are within reach, and that scientific research is the key to getting us there. That’s why so many of our formulas feature specific ingredients and amounts based on scientific studies.

Solgar Folate 1000 mcg, 120 Tablets - 1000 mcg Bio-active Metafolin - Heart Health - Vegan, Gluten Free, Dairy Free, Kosher - 120 Servings

$32.99
$23.17
 in stock
4 new from $23.17
Free shipping
as of August 24, 2025 10:02 am

Features

  • BODY READY – In order for the body to use Folic Acid, it must undergo a series of biochemical steps. The active folate in Solgar Folate is Metafolin (L-methyfolate) which is bioidentical to the bioactive form, which means no conversion by the body.
  • BENEFITS – The active folate in this formulation helps in promoting heart health as well as providing support for a healthy nervous system as well as the formulation of healthy red blood cells.
  • SUITABLE FOR VEGANS – All capsules are non-GMO and certified gluten free. They are also free of wheat, dairy, soy, yeast, sugar, sodium, artificial flavors, sweeteners, preservatives and colors.
  • The Gold Standard; For over 70 years, Solgar has been committed to quality, health, and well-being. Our mission is to create the finest nutritional supplements in small batches, through tireless research, using only the finest raw materials

NOW Supplements, Methyl Folate 1,000 mcg, Metabolically Active Folate*, Co-Enzyme B Vitamin, 90 Tablets

$21.99
$11.28
 in stock
12 new from $11.28
Free shipping
as of August 24, 2025 10:02 am

Features

  • CO-ENZYME B VITAMIN/1,000 mg TABLETS: Methylfolate is the biologically active, naturally occurring form of folate that is used for fundamental body functions like normal cell division and the synthesis of neurotransmitters and DNA.
  • METABOLICALLY ACTIVE FOLATE/SUPERIOR BIOAVAILABLITY: Quatrefolic is a patented form of methylfolate that has demonstrated bioavailability superior to that of folate from dietary sources.
  • CERTIFICATIONS/CLASSIFICATIONS: Non-GMO, Vegan/Vegetarian
  • GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
  • Packaged in the USA by a family owned and operated company since 1968

Jarrow Formulas Extra Strength Methyl B-12 & Methyl Folate - 100 Chewable Tablets, Lemon Flavored - Bioactive Vitamin B12 & B9 - Cellular Energy and Cardiovascular Support (Packaging May Vary)

$22.99
$13.99
 in stock
2 new from $13.99
Free shipping
as of August 24, 2025 10:02 am

Features

  • EXTRA STRENGTH FORMULA: Jarrow Formulas Methyl B-12 1000 mcg and Methyl Folate 400 mcg Extra Strength, cellular energy support formula with P-5-P deliver biologically active forms of vitamin B12, B9 and B6 that support cellular energy metabolism and cardiovascular health(1)
  • CELLULAR ENERGY SUPPORT: This combination of B vitamins helps convert carbs, fats and proteins to cellular energy(1)
  • METHYLATED FORM: Methyl B-12 is better retained than common B-12, Methyl Folate is unlike synthetic folic acid that may mask vitamin B12 deficiency(1)
  • FITS YOUR LIFE: The vitamin B12 and methyl folate supplements are vegan, Non-GMO and gluten free for a tasty, lemon flavored, dietary supplement that support cellular energy(1); contains up to a 100 day supply
  • SUPERIOR SCIENCE, SMARTER FORMULAS: Informed by strong scientific research, Jarrow Formulas products are carefully crafted to ensure you get the benefit of each and every vitamin, mineral and supplement

Spring Valley - Folic Acid 800 mcg, 400 Tablets by Spring Valley

$12.99
$11.74
 out of stock
46 new from $9.99
Free shipping
as of August 24, 2025 10:02 am

Features

Part Number BD27736
Model BD27736
Is Adult Product
Size 400 Count (Pack of 1)

Jarrow Formulas Methyl Folate 400 Mcg - 60 Veggie Caps - Dietary Supplement - Highly Biologically Active Form Of Folate - 4th Generation Folic Acid Technology - 60 Servings (PACKAGING MAY VARY)

$11.99
$7.99
 in stock
3 new from $7.99
Free shipping
as of August 24, 2025 10:02 am

Features

  • Cardiovascular and Neurologic Health support supplement: Contains one 60 count bottle of Jarrow Formulas Extra Strength Methyl Folate 400 mcg Veggie Capsules for a 60-day supply
  • Dietary supplement with 400 mcg of Methyl Folate (5-MTHF), a biologically active form of Vitamin B9 to support cardiovascular health, proper cell division and neurologic health*
  • Features Quatrefolic methyl folate that can cross the blood-brain barrier*
  • Suggested Use: Adults, take one capsule once a day with or without food, or as directed by your qualified healthcare professional
  • *These statements have not been evaluated by the Food and Drug Administration; this product is not intended to diagnose, treat, cure, or prevent any disease

Spring Valley Folate Dietary Supplement, 1,333 mcg, 400 Count + STS Sticker.

$14.97  in stock
as of August 24, 2025 10:02 am

Features

Part Number STS-03

Organic Methyl Folate 1000 mcg + Methyl B12 Cofactor (300 Servings) – Metabolically Active 5-MTHF Form, Organic Berry Flavor, Liquid Sublingual Form – Mood, Cognition, Methylation, Pregnancy

$30.00
$21.97
 in stock
as of August 24, 2025 10:02 am

Features

  • BIOLOGICALLY ACTIVE FORM OF FOLATE (1 mg or 1000 mcg) : L-Methylfolate is the biological active form of Folate. It immediately absorbs into bloodstream and requires no processing by the body. The 1 mg dose is ideal to address daily Folate nutritional needs.*
  • ESSENTIAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships. Both are crucial in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.*
  • ENHANCED SUBLINGUAL ABSORPTION, CHERRY FLAVOR: The liquid sublingual form of L-methylfolate immediately absorbs directly into the bloodstream with higher overall absorption.*
  • SUPPORTS HEALTHY METHYLATION: The L Methyl Folate form of Folate is essential for healthy methylation especially for those with MTHFR gene.*
  • PREGNANCY, BRAIN, MOOD, ENERGY SUPPORT, CARDIOVASCULAR: 1 mg of Methylfolate supports healthy baby development during pregnancy. It is also essential to neurotransmitters production involved in concentration, sleep, energy, hormones & mood.* Methylfolate also supports heart health and nerve function by supporting healthy homocysteine levels and nitric oxide production.*

The Video Review of Best folate supplements

Conclusion

Our best overall folate supplements, the Perception and the reviews helps assist to choose you the product better. We hope our reviews buyer guide of these folate supplements will help you pick the perfect folate supplements for you and your buying decision making.

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