In this guide today, we are here with our in-depth review of the best preservative free eye drop. There are plenty of choices with multiple websites and therefore difficult to choose the best one. We recommend to read the guide and choose the one that suits your need as we review products based on the various options, features, price, quality and many more . To avoid this dilemma, we recommend to read this guide and review. It gives you insider information on how to choose the best preservative free eye drop for your needs and budget.
This is the ultimate buyers guide preservative free eye drop.
A Quick Comparison of Our Favorites
The Best preservative free eye drop
Refresh Plus Lubricant Eye Drops, Value Size, 70-0.01 Fluid Ounce (0.4 ml) Containers
$21.62 in stock
13 new from $19.99
Free shipping
Amazon.com
as of August 22, 2025 9:53 am
Features
- Original strength, preservative-free formula
- Relieves mild symptoms of eye dryness
- Instantly moisturizes and lubricates
- Designed to act like your own natural tears
- Great for sensitive eyes
Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 20ml(Pack of 2 – 10mL bottles)
$18.97 in stock
14 new from $18.97
Free shipping
Amazon.com
as of August 22, 2025 9:53 am
Features
- Fast acting hydration for sensitive eyes
- Preservative free tear evaporation protection
- Nano droplets for better coverage
Systane Hydration Multi-Dose Preservative-Free Eye Drops Dry Eye Relief Twin Pack (2x10ml)
$18.98 in stock
9 new from $18.98
Amazon.com
as of August 22, 2025 9:53 am
Features
- Hydrates fast and provides long-lasting relief for dry eyes
- Preservative free eye drops
- Contains hyaluronate for advanced hydration
- Safe for use with all contact lenses
- Extra moisturizing eye drops for sensitive eyes
Refresh Plus Lubricant Eye Drops, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 50 Count, Packaging May Vary
$15.99 in stock
12 new from $15.97
Free shipping
Amazon.com
as of August 22, 2025 9:53 am
Features
- Original strength, preservative-free formula
- Relieves mild symptoms of eye dryness
- Instantly moisturizes and lubricates
- Designed to act like your own natural tears
- Great for sensitive eyes
TheraTears Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, Preservative Free Eye Drops, 30 Single-Use Vials
$10.98 in stock
9 new from $10.98
Free shipping
Amazon.com
as of August 22, 2025 9:53 am
Features
- Dry eye relief without preservatives for sensitive eyes: TheraTears preservative-free lubricating eye drops in single-use vials provide immediate, long-lasting relief from dry eye symptoms
- Instant hydration: TheraTears eye drops restore eyes’ natural balance and deliver fast hydration relief for dry eyes, because hydration is as essential for eye health as it is for the rest of the body
- Electrolytes: TheraTears eye drops’ unique formula contains OxyLytes, the 5 vital electrolytes found in natural tears
- Created by an ophthalmologist: The TheraTears formula was created by an ophthalmologist, following 18 years of research, for a one-of-a-kind eye drop
- Doctor-recommended: TheraTears is a doctor-recommended brand (per ProVoice Survey data collected 9/1/23-8/31/24), created to bring balance and hydration to dry eyes; your purchase may be FSA/HSA eligible, check your health plan for details
Biotrue Hydration Boost Eye Drops, Preservative Free, Soft Contact Lens Friendly for Irritated and Dry Eyes from Bausch + Lomb, Preservative Free, Naturally Inspired, 0.33 FL OZ (10 mL), Pack of 2
out of stock
Amazon.com
as of August 22, 2025 9:53 am
Features
- NATURALLY INSPIRED INGREDIENTS: Biotrue Hydration Boost Eye Drops are enhanced with HA (Hyaluronan), Antioxidant, and Electrolyte and provide instant moisture for dry eyes.
- INSTANT MOISTURE: For dry, irritated eyes due to screen and environmental stressors.
- Special preservative free, multi-dose bottle.
- BIOTRUE EYE DROPS: Not only are the Hydration Boost Eye Drops free of preservatives but they are also pH balanced for comfort.
- EYE DROPS & MORE: Bausch + Lomb makes eye care products you can trust, from contact lens solutions to eye drops, vitamins, & ointments to help your eyes feel moisturized and protected.
Systane Ultra Preservative-Free Eye Drops 10ml
$13.39 in stock
13 new from $13.39
Free shipping
Amazon.com
as of August 22, 2025 9:53 am
Features
- Preservative-Free Lubricant Eye Drops
- Fast-Acting Hydration and lasting dry eye relief
- Moisture rich formula for sensitive eyes
- Tear evaporation protection
Refresh Optive Mega-3 Lubricant Eye Drops, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 60 Count
$21.75 in stock
11 new from $21.75
Free shipping
Amazon.com
as of August 22, 2025 9:53 am
Features
- FAST-ACTING: Rapid relief to comfort dry, irritated eyes
- LASTING RELIEF: Soothes and prevents further irritation
- TRIPLE-ACTION FORMULA: Lubricates, hydrates, and protects tears from evaporating
- PRESERVATIVE-FREE: Enhanced with antioxidants and plant-based Flaxseed Oil (inactive ingredients) which contains omega-3s
- ADVANCED HYDRATION: Innovated with patented HydroCell technology that enables rehydration
Refresh Optive Lubricant Eye Drops, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 60 Count
$22.26 in stock
8 new from $19.71
Free shipping
Amazon.com
as of August 22, 2025 9:53 am
Features
- Dual-action formula lubricates and hydrates
- Relieves mild symptoms of eye dryness
- Works fast by delivering soothing moisture
- Preservative-free for sensitive eyes
- Value size: 60 on-the go, single-use vials
iVIZIA Sterile Lubricant Eye Drops for Dry Eyes, Preservative-Free, Moisturizing, Dry Eye Relief, Contact Lens Friendly, 0.33 fl oz bottle
$11.96 out of stock
18 new from $11.35
Free shipping
Amazon.com
as of August 22, 2025 9:53 am
Features
- iVIZIA Sterile Lubricant Eye Drops for Dry Eyes, Preservative-Free, Moisturizing, Dry Eye Relief, Contact Lens Friendly, 0.33 fl oz bottle.
- Unique Formulation: Hydrating polymers form a protective matrix, moisturizing Hyaluronic Acid holds up to 1000x its weight in moisture, and Trehalose (synthetic ingredient also found in desert plants).
- Free of Irritating Preservatives: Sterile, safe for use with contact lenses
- Patented ABAK Bottle: preservative-free, dispenses drop-by-drop, and does not stream. The ergonomic bottle is easy to open, easy to hold and squeeze.
- iVIZIA – We See a Better Way: for healthy, comfortable eyes
The Video Review of Best preservative free eye drop
Conclusion
Our best overall preservative free eye drop, the Perception and the reviews helps assist to choose you the product better. We hope our reviews buyer guide of these preservative free eye drop will help you pick the perfect preservative free eye drop for you and your buying decision making.