FRONTLINE Plus for Dogs Flea and Tick Treatment (Large Dog, 45-88 lbs.) 3 Doses (Purple Box)

The 10 Best dog medicine for ticks and fleas Our Picks

Finding a dog medicine for ticks and fleas that suits your need and does its job well can be challenging. Overall, our tester reviews these dog medicine for ticks and fleas with giving ratings and marks for its durability, ease of setup and use. Also the dog medicine for ticks and fleas price will be fairly matched the product’s performance, plus with the attractive and sturdy design etc that comes with the product. We conducted hands-on testing for dog medicine for ticks and fleas and have the details guide and list provided below.

This is the ultimate buyers guide dog medicine for ticks and fleas.

A Quick Comparison of Our Favorites

The Best dog medicine for ticks and fleas

PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, Waterproof Topical, Fast Acting, Large Dogs (45-88 lbs), 3 Doses

$28.99
$23.59
 in stock
3 new from $23.59
Free shipping
as of June 16, 2025 1:21 pm

Features

  • EFFECTIVE, WATERPROOF FLEA TREATMENT FOR DOGS: PetArmor Plus is a waterproof, flea & tick topical prevention for dogs that kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application.
  • TRUSTED, VET QUALITY* FORMULA: Containing fipronil and (S)-methoprene, the same active ingredients as FRONTLINE Plus for Dogs. PetArmor Plus for Dogs has a powerful formula that starts to kill fleas within 24 hours.
  • BREAK THE FLEA CYCLE: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Dog Flea Treatment works by effectively breaking the flea life cycle! Kill flea eggs and larvae to prevent re-infestation.
  • FAST ACTNG LONG-LASTING FLEA AND TICK PROTECTION: One application of PetArmor Plus lasts up to 30 days nose to tail. A 6-dose package lasts up to six months.
  • EASY-TO-USE, LONG-LASTING: PetArmor Plus flea and tick treatment comes with three (3) waterproof topical applications that provides your pet flea protection and control for three (3) months.

K9 Advantix II XL Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs Over 55 lbs. | 4-Mo Supply

 in stock
as of June 16, 2025 1:21 pm

Features

  • K9 Advantix II Extra Large Dog 30-day treatment & prevention protects dogs over 55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
  • Kills fleas within 12 hours of application
  • Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
  • Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
  • No prescription needed

PetArmor CAPACTION (nitenpyram) Oral Flea Treatment for Dogs, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Dogs Over 25 lbs, 6 Doses

$26.94  in stock
3 new from $26.94
Free shipping
as of June 16, 2025 1:21 pm

Features

  • FAST-ACTING: One oral flea tablet starts killing fleas within 30 minutes of administration.
  • SAFE TO USE: This oral flea medication is safe for puppies, dogs, cats, and kittens from 25lbs. and over, when used as directed.
  • TREAT RE-INFESTATIONS FAST: If your pet gets re-invested with fleas simply apply another dose as often as once a day. CapAction Flea Pills are even safe for use on pregnant or breeding dogs.
  • EASY TO USE: Without the mess and rubbing off of a flea and tick topical treatment and without the need of a veterinarian prescription this dog flea tablet is administered orally to kill adult fleas fast.
  • KILL FLEAS EFFICIENTLY: CapAction flea treatment has 6 doses and kills adult fleas that may cause allergy dermatitis.

K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21 - 55 lbs. | 2-Mo Supply

 in stock
as of June 16, 2025 1:21 pm

Features

  • K9 Advantix II Large Dog 30-day treatment & prevention protects dogs 21-55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
  • Kills fleas within 12 hours of application
  • Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
  • Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
  • No prescription needed

PetArmor for Dogs, Flea and Tick Treatment for Large Dogs (45-88 Pounds), Includes 3 Month Supply of Topical Flea Treatments

$14.40  in stock
as of June 16, 2025 1:21 pm

Features

  • DOG FLEA AND TICK CONTROL: PetArmor topical flea and tick treatment kills adult fleas, ticks and chewing lice. Backed by the PetArmor Protection Guarantee.
  • VET QUALITY FORMULA: Dog flea treatment contains the active ingredient fipronil.
  • FAST-ACTING FLEA TREATMENT: PetArmor flea treatment for dogs can help you stop an existing flea or tick infestation.
  • FLEA AND TICK PREVENTION: PetArmor for dogs helps you protect your furry family member from brown dog ticks, American dog ticks, lone star ticks, and deer ticks (which may transmit Lyme disease).
  • INCLUDES: Three (3) topical application tubes for a 3 month supply of dog and flea and tick control. For best results, apply flea & tick treatment for dogs directly to dry skin on your dog's back-between the shoulder blades-on a monthly basis.

FRONTLINE Plus for Dogs Flea and Tick Treatment (Large Dog, 45-88 lbs.) 3 Doses (Purple Box)

$44.99
$39.98
 in stock
2 new from $39.98
Free shipping
as of June 16, 2025 1:21 pm

Features

  • Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
  • Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
  • Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
  • FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
  • Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations

Amazon Basics Flea and Tick Topical Treatment for Small Dogs (4-22 pounds), 3 Count (Previously Solimo)

$19.24  in stock
as of June 16, 2025 1:21 pm

Features

  • Same product, new look - This product is identical in manufacturing and formulation as the Solimo brand
  • One 3 dose pack of Amazon Basics Flea and Tick Treatment for Dogs, Small (5-22 lbs), 3 Count (Previously Solimo)
  • Amazon Basics Flea & Tick starts eliminating fleas and ticks within 24 hours of treatment
  • Active ingredients Fipronil and (s)-methoprene prevent flea infestations by killing flea eggs, flea larvae, mosquitos, biting flies and chewing lice
  • One application provides up to 30 days of protection

FRONTLINE Plus for Dogs Flea and Tick Treatment (Small Dog, 5-22 lbs.) 3 Doses (Orange Box)

$44.99
$39.98
 in stock
2 new from $39.98
Free shipping
as of June 16, 2025 1:21 pm

Features

  • Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
  • Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
  • Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
  • FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
  • Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations

Seresto Large Dog Vet-Recommended Flea & Tick Treatment & Prevention Collar for Dogs Over 18 lbs. | 8 Months

 in stock
as of June 16, 2025 1:21 pm

Features

  • Vet-recommended, premium flea & tick protection for dogs & puppies without the price tag
  • Long-lasting flea and tick collar kills & repels fleas for 8 continuous months
  • Seresto is the #1 veterinarian recommended flea & tick collar*
  • Starts working within 24 hours to kill & repel fleas by contact so pests don’t have to bite your dog to die
  • Hassle-free, non-greasy, easy-to-use flea & tick protection

K9 Advantix II Medium Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 11-20 lbs. | 2-Mo Supply

 in stock
as of June 16, 2025 1:21 pm

Features

  • K9 Advantix II Medium Dog 30-day treatment & prevention protects dogs 11-20 lbs. from fleas, ticks, mosquitoes, biting flies and lice
  • Kills fleas within 12 hours of application
  • Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
  • Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
  • No prescription needed

The Video Review of Best dog medicine for ticks and fleas

Conclusion

Our best overall dog medicine for ticks and fleas, the Perception and the reviews helps assist to choose you the product better. We hope our reviews buyer guide of these dog medicine for ticks and fleas will help you pick the perfect dog medicine for ticks and fleas for you and your buying decision making.

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