Finding a ergonomic mice that suits your need and does its job well can be challenging. Overall, our tester reviews these ergonomic mice with giving ratings and marks for its durability, ease of setup and use. Also the ergonomic mice price will be fairly matched the product’s performance, plus with the attractive and sturdy design etc that comes with the product. We conducted hands-on testing for ergonomic mice and have the details guide and list provided below.
In this in-depth review guide, we will discuss about the best ergonomic mice.
The Best ergonomic mice
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Anker 2.4G Wireless Vertical Ergonomic Optical Mouse, 800 / 1200 /1600 DPI, 5 Buttons for Laptop,...
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![J-Tech Digital Ergonomic Mouse with Wireless Connection, Removable Palm Rest, Thumb Buttons, Rechargeable Battery, 800, 1200, 1800, 3200 Adjustable DPI; Compatible with Windows and MAC OS [V638]](https://m.media-amazon.com/images/I/41Oli99XqeL._SL160_.jpg)
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shoplease Wired Vertical Mouse, Optical Ergonomic Mouse with 4 Adjustable DPI 800/1200/2000/3200,...
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The Best ergonomic mice
Anker 2.4G Wireless Vertical Ergonomic Optical Mouse, 800 / 1200 /1600 DPI, 5 Buttons for Laptop, Desktop, PC, Macbook - Black
$29.99
in stock
2 used from $29.19
Free shipping
Amazon.com
as of August 2, 2025 1:24 pm
Features
- Scientific ergonomic design encourages healthy neutral "handshake" wrist and arm positions for smoother movement and less overall strain.
- 800 / 1200 / 1600 DPI Resolution Optical Tracking Technology provides more sensitivity than standard optical mice for smooth and precise tracking on a wide range of surfaces.
- Added next/previous buttons provide convenience when webpage browsing; the superior choice for internet surfers, gamers and people who work at length at the computer.
- Enters power saving mode (power is cut off completely) after 8 minutes idle, press right or left button for it to wake. Product dimensions: 120*62.8*74.8 mm; product weight: 3.4 oz.
- Package includes: 1 Anker Wireless Vertical Ergonomic Optical Mouse (2 AAA batteries not included), 1 2.4G USB receiver (in the bottom of the mouse), 1 instruction manual. 18-month hassle-free warranty.
Vassink Ergonomic Mouse, Rechargeable Wireless Mouse, 2.4GHz Rechargeable Wireless Vertical Optical Mice with USB Receiver, 6 Buttons, 800/1200/1600 DPI, for Laptop, PC, Computer Black
$14.99 in stock
Amazon.com
as of August 2, 2025 1:24 pm
Features
- ☛【Ergonomics-Wireless Mouse】The vertical wireless ergonomic mouse is designed to fit the size and contour of the palm, reducing the pressure on the palm and making your control of the wireless mice more comfortable and natural.
- ★【Efficient and Sensitive-Easy to Use】The ergonomic mouse has 6 convenient buttons design, plug and play; Adjustable mouse movement speed. Optical tracking technology has higher sensitivity than standard optical mouse, usable Smooth and precise tracking on a variety of surfaces.
- ☛【Quiet Design-Fashionable Charging】The wireless mouse adopts a button mute design, which is more suitable for public places such as libraries, dormitories, offices, high-speed rail planes, etc.; with built-in lithium battery and USB data cable charging device, making your use more fashionable Convenient.
- ★★★【Long Life-More Durable】The high-quality optical wireless mouse has been tested for over 5 million mouse clicks. The rechargeable feature makes this wireless mouse more durable.(It is better to use it after receiving the mouse fully charged)
- ☛【Strong Compatibility-Vassink Service】Support Windows 2000/ ME/ XP/ 7/ 8/ 10/ Vista/98, Mac OS, Linux, etc. Suitable for notebooks, PCs, laptops, computers, Macbooks and other equipment. We provide 12 months of worry-free after-sales service. If you encounter any problems with the wireless mouse during use, please feel free to contact us.
Logitech Lift Vertical Ergonomic Mouse, Wireless, Bluetooth or Logi Bolt USB receiver, Quiet clicks, 4 buttons, compatible with Windows/macOS/iPadOS, Laptop, PC - Graphite
$77.99
in stock
12 new from $66.99
10 used from $55.74
10 used from $55.74
Free shipping
Amazon.com
as of August 2, 2025 1:24 pm
Features
- Lift yourself up: When desk work gets you down, lift yourself up with this Logitech Wireless Ergonomic Mouse - a great fit for small to medium right hands
- Raise your hand into comfort with this computer mouse wireless: Rest on Lift upright mouse throughout the day with a softly textured grip and snug thumb rest for level-above coziness
- 57 degrees of soothe: This wireless ergonomic mouse promotes a more natural posture in the forearm for comfort and productivity, for day-long comfort and productivity
- Relax into focus: Settle into work with this ergonomic wireless mouse featuring easy-to-reach customizable buttons, whisper-quiet clicks, and a SmartWheel for smooth, seamless scrolling
- Ergo-certified: This wireless vertical mouse has been designed, developed, tested, and approved according to criteria set out by leading ergonomists
Logitech MX Vertical Wireless Mouse – Advanced Ergonomic Design Reduces Muscle Strain, Control and Move Content Between 3 Windows and Apple Computers (Bluetooth or USB), Rechargeable, Graphite
$94.99 in stock
19 new from $90.99
3 used from $64.16
3 used from $64.16
Free shipping
Amazon.com
as of August 2, 2025 1:24 pm
Features
- Made in VIET NAM
Logitech ERGO M575 Wireless Trackball Mouse - Easy thumb control, precision and smooth tracking, ergonomic comfort design, for Windows, PC and Mac with Bluetooth and USB capabilities - Graphite
$46.71
in stock
1 used from $46.71
Free shipping
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as of August 2, 2025 1:24 pm
Features
- Ergonomic comfort design, relaxed hand and arm: The comfortable, sculpted ergonomic shape of this mouse naturally fits your hand
![J-Tech Digital Ergonomic Mouse with Wireless Connection, Removable Palm Rest, Thumb Buttons, Rechargeable Battery, 800, 1200, 1800, 3200 Adjustable DPI; Compatible with Windows and MAC OS [V638]](https://m.media-amazon.com/images/I/41Oli99XqeL._SL500_.jpg)
J-Tech Digital Ergonomic Mouse with Wireless Connection, Removable Palm Rest, Thumb Buttons, Rechargeable Battery, 800, 1200, 1800, 3200 Adjustable DPI; Compatible with Windows and MAC OS [V638]
$26.95
out of stock
Amazon.com
as of August 2, 2025 1:24 pm
Features
- – The J-Tech Digital V638’s comfortable, ergonomic “handshake” design greatly reduces arm/wrist/hand strain. Back/forward thumb buttons provide extra convenience. (Button functionality can also be changed or reassigned using third-party software.) Works on most non-metallic surfaces. The built-in lithium battery is fully rechargeable.
- – This ergonomic mouse features a detachable non-skid anti-sweat palm rest that reduces drag, making it easier to maneuver the mouse across the surface of a mousepad, tabletop, desktop, etc.
- – Users can adjust responsiveness to 800, 1200, 1600 or 3200 DPI depending on their need and/or preference. 360-degree signal allows for full freedom of ergonomic mouse movement. Optical Tracking Technology ensures greater sensitivity for precise tracking on a wide range of surfaces.
- – Compatible with Windows 7/8/10, XP, Vista 7/8, Linux, Mac OS, etc. A USB Nano Receiver/Dongle Transceiver connects the ergonomic mouse wirelessly to your computer, so you aren’t tethered by a cable.
- – The V638 ergonomic mouse, like all J-Tech Digital Products, includes a One-Year Manufacturer Warranty and free lifetime technical support from our US-based Customer Support Team (Available M-F 9AM-6PM CST). Contact information available on the J-Tech Digital Seller Page.
shoplease Wired Vertical Mouse, Optical Ergonomic Mouse with 4 Adjustable DPI 800/1200/2000/3200, 5 Buttons USB Computer Mouse , Better for Large and Medium Sized Hands
$9.99 in stock
Amazon.com
as of August 2, 2025 1:24 pm
Features
- 【Ergonomic Design】-Scientific ergonomic design encourages healthy neutral "handshake" wrist and arm positions for smoother movement and less overall strain. (Note: it is a right-handed mouse)
- 【More Adjustment】-800 / 1200 / 2000 / 3200 Resolution Optical Tracking Technology provides more sensitivity than standard optical mice for smooth and precise tracking on a wide range of surfaces.
- 【Useful Page Buttons】-Added next/previous buttons provide convenience when webpage browsing; the superior choice for internet surfers, gamers and people who work at length at the computer.
- 【No Deed for Battery】-Plug and Play mouse with USB 2.0 interface, easy to start to use with standard setting function. High quality rubber coating surface gives it a feel-good touch
- 【Wide compatibility】-Compatible with Windows 7/8/10 / Vista / XP / 2000, Mac OS, Linux (NOTE: the forward and backward buttons are not recognized on Mac). Plug and play.
Solopen Wireless Mouse, Ergonomic Mouse-2.4GHz Wireless Vertical Mouse with 3 Adjustable DPI 800/1200/1600,6 Buttons,Compatible with PC,Desktop - Black
out of stock
Amazon.com
as of August 2, 2025 1:24 pm
Features
- 【Ergonomic wireless mouse】The vertical mouse is ergonomic and comfortable in the hand to effectively protect wrist health. At the same time, regular use of ergonomic mouse can also relieve wrist pain, shoulder fatigue, carpal tunnel syndrome and tendonitis.
- 【High-speed wireless transmission】Wireless optical mouse has 2.4G wireless transmission, up to 33FT transmission distance. The bottom has a USB receiver, plug and play. Desktop, laptop universal.
- 【Three-stop DPI Switching】The wireless vertical mouse provides three adjustable DPI settings (800/1200/1600), which can be programmed according to your specific needs, and can be easily used for office and game design.
- 【Shortcut Side Keys】Click the forward and backward keys on the left side of the wireless mouse to switch web pages with one click, allowing you to easily navigate your online life and browse documents quickly.
- 【High efficiency and energy saving】Ergonomic mouse with replaceable battery design, easy to replace batteries, only two AAA batteries, energy saving and long battery life.
ASOYIOL Ergonomic Mouse Wireless,Ergo Mouse Vertical Mouse 6 Buttons 3 Adjustable DPI 800/1200/1600 Levels,Sideways Mouse Right Handed for PC Laptop
out of stock
Amazon.com
as of August 2, 2025 1:24 pm
Features
- Ergonomic Design make your hand more healthier and less overall strain. Widely compatible with Windows 2000/ XP/Vist /7/8/10/Linux.Easy to Use-USB receiver at the bottom of mouse and need battery. Power saving mode after 8 minutes idle
- Stable connection with less noise click-reliable 2.4G wireless mouse connection with high performance with 33ft.Quieter click makes you concentrate on work without disturbing others.
- Vertical Ergonomic Mouse easily adjusts the DPI of the mouse. 800/1200/1600 DPI Resolution Optical tracking on a wide range of surfaces and more precise.
- Six buttons is a nice choice for computer mouse, gamers and other network activity.Especially the "Page Back" and "Page Forward" functionality.
- Excellent Service for your satisfied, If you have any questions for our ergonomic vertical mouse,Please feel free to contact us for Replacement or Refund.Hope you have a pleasure purchase.
ASOYIOL Ergonomic Mouse Wireless,Rechargeable Vertical Mouse with USB Receiver,6 Buttons 800/1200/1600 Computer Mouse for Laptop
$24.99
in stock
2 new from $24.99
Free shipping
Amazon.com
as of August 2, 2025 1:24 pm
Features
- 【Ergonomic Mouse Wireless】Naturally aligns your hand in a handshake position to reduce wrist strain and promote comfort during long hours of computer use. Ergonomic Vertical Mouse--Ergo mouse designed for right handed that promotes natural hand posture while using the mouse for long time
- 【Wireless Convenience 】Powered by AAA batteries. offering reliable cord-free operation for a tidy desk.Widely compatible with Windows 2000/XP/Vist /7/8/10/ME/Vista/98,Linux,Mac OS, etc. Suitable for Macbooks, Pc, laptops, computers, notebook and other equipment.
- 【3 Level DPI Adjustment】 Easily switch between high-precision cursor speeds 1000/1200/1600 DPI for optimal control in different tasks . Mouse sensitivity can be changed with the DPI control button; Adjustable 3 levels of the 1000/1200/1600 DPI resolution optical tracking on a wide range of surfaces and more precise.
- 【Enhanced Comfort & Grip】 Features textured side grips for secure handling and a contoured shape that comfortably supports your hand and thumb. Mouse ergonomice with Six buttons is a nice choice for computer mouse, gamers and other network activity.Ergo mouse Especially the "Page Back" and "Page Forward" functionality.
- 【Easy to Use】Ergonomic wireless mouse USB receiver at the bottom of mouse and battery power supply. Power saving mode after 8 minutes idle. Wireless ergonomic vertical mouse provides up to 10 meters operation range; ,Works seamlessly with Windows, macOS, Chrome OS, and Linux computers/laptops via included USB receiver (Plug-and-Play).
The Video Review of Best ergonomic mice
Final thoughts
When you’re looking for ergonomic mice, you’ll want to keep a few things in mind. First, decide what you want to use the ergonomic mice for. Next, check the product reviews with comparision which we have listed as well. Once you’ve decided on ergonomic mice you want to buy ergonomic mice, look at the reputation of the manufacturer as well. You can compare prices and quality together before you make your purchase.